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KMID : 0356620120270040308
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Journal of Korean Society of Endocrinology
2012 Volume.27 No. 4 p.308 ~ p.313
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Pancytopenia Associated with Hypopituitarism in an Acromegaly Patient: A Case Report and a Review of the Literature
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Koh Jung-Hee
Lee Yong-Jae
Kang Ji-Hyun
Choi Bo-Kwang
Jeon Yun-Kyung
Kim Sang-Soo
Kim Bo-Hyun
Kim In-Joo
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Abstract
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We present the case of a patient with acromegaly who had pancytopenia with hypopituitarism secondary to the excision of a pituitary macroadenoma and radiation therapy. A 28-year-old man presented with pancytopenia and serum electrolyte abnormalities. He was diagnosed with acromegaly and underwent surgery and gamma-knife radiotherapy for a pituitary macroadenoma at the age of 22 years. A recent brain magnetic resonance imaging showed an empty sella, and the basal hormonal profile demonstrated deficiencies of pituitary hormones except thyrotropin. As presenting pancytopenia, his bone marrow biopsy showed hypocellular marrow. The total number of hemocytes increased after hydrocortisone replacement. Hypopituitarism was a possible cause of pancytopenia, and glucocorticoids had crucial effects on converting pancytopenia to normal in this case.
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KEYWORD
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Acromegaly, Hypopituitarism, Pancytopenia
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